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02 MRI-guided Radiofrequency Ablation of Liver Tumors
The purpose of this project is to implement radiofrequency (RF)
ablation of malignant liver tumors under MR imaging guidance. This
procedure intends to render percutaneous image-guided thermoablation
of liver tumours more reproducible and more precise. MRI provides a
unique method to predict the coagulation zone size via real time
thermometry. MR images are transmitted from the MR scanner to a
computer that calculates the temperature maps in the ablation
zone. The temperature-time evolution enables the calculation of a
thermal dose, from which tissue coagulation can be predicted
accurately, thus enabling the operator to determine the cut-off point
for the RF energy application. The goal is to develop and implement a
software tool based on MR image data sets that enables the radiologist
to simulate the position of multipolar RF electrodes depending on the
size and geometry of the individual tumor and the convection phenomena
occurring around vessels.
Sub Projects
02/1 Clinical validation
Experimental validation of new devices, software and methods and implementation into clinical practice will be carried out at the Radiology Department of the Geneva University Hospital.
The goal of this sub-project is the development of image processing methods and statistical techniques to build a generic model of respiratory organ motion. As an example, the shape and motion of the liver are modelled.
The goal of this subproject is to create a comprehensive simulation environment
for the planning and training of RF-thermoablation procedures. It is planned as
a common research and development effort between Co-Me (Radiology, HUG;
Computer Vision Lab, ETHZ; IT'IS foundation) and the VICORA consortium (MeVis,
Bremen; Celon AG; Universities of Munich, Tübingen and Lübeck). Development
within the Co-Me network will concentrate on training simulation and validation
aspects of the overall project.
Project Coordination
Last update on 2009-05-19.
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