02/2 Generic Model of Organ Motion
Respiratory organ motion is a complicating factor in many treatments.
The shape of abdominal organs and their internal structures show large
variations between subjects and the breathing pattern may vary in frequency,
amplitude and shape, even for a single subject. The development of a
detailed and realistic organ model permits to learn more about this motion
and to improve treatments like tumour ablation or radiation therapy. Such a
model will also provide valuable knowledge for other applications like
realistic organ simulation or model-based segmentation.
The main goal of this work is to develop image processing methods and
statistical techniques to build a generic model of organ motion. The motion
of mass points within the liver is determined based on time-resolved 3D MR
sequences, which are acquired using an internal gating technique developed
in Co-Me phase I. This allows to analyse intra-subject and inter-subject
variabilities of organ shape and motion. A further step is to develop
different methods for the statistical description of the motion
characteristics. A key element in this research is the reduction of the
resulting model to its significant modes of variation and a practical number
of parameters or predictors. Such predictors can then be used to determine
the patient specific organ motion from a minimum amount of measured data.
Although the model and the statistical framework are generic, they will be
developed for the liver as an example organ.
Please consult the project
homepage for more information.
Last update of project infos on 2010-11-23.