04/9 Tumor vessel tree
Our partner, the team of M. Rudin (ETH Zürich) performs in vivo
studies of a mouse model to validate simulations of D. Szczerba and
his team. Their in vivo imaging modalities (PET and MRI), however, do
not allow visualizing the smallest blood vessels
(capillaries). Therefore, we carry out post mortem imaging of the same
tumors using high-resolution computed tomography based on highly
intense monochromatic X-rays.
We are going to visualize the blood vessel systems of the tumors
down to the smallest blood vessels with the aim to extract parameters
characteristic for the tumor formation, which can be applied for the
validation of simulations and to calibrate the MR images, which should
support extracting blood vessel diameters necessary for flow
simulations.
The huge datasets of GB size have to be translated from
voxels-based representation to a vector-based one, which includes the
segmentation of the vessels. The segmentation, however, can only be
realized either incorporating appropriate tissue preparation such as
barium sulfate staining or applying phase contrast techniques.
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