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Neuro

01 Computer Aided and Image Guided Support for the Treatment of Neurodegeneration and Brain Tumours

A patient is treated with the non-invasive MR guided focused ultrasound system.

The overall aim of this project is to develop a more effective and less invasive treatment for neurological diseases such as neurodegeneration and brain tumours.

In order to achieve a targeted delivery of therapeutic agents to the Central Nervous System, this project explores the potential of applying focused ultrasound to the non-invasive temporal openings of the blood-brain barrier. It will also clarify the conditions needed for a safe human application to blood-brain barrier openings and prepare the first clinical studies for Alzheimer treatment.
Research will be conducted jointly with the NCCR Neural Plasticity and Repair.

At the same time, basic and clinical research in glioma formation and image guided tumor surgery will be carried out. This research will address the multiscale, physical, chemical and physiological modeling of glioma development and infiltration. It will also focus on neuronavigation for the resection of cortical and deep seated brain tumors. This work pushes the precision limits of current neuronavigation approaches and aims at establishing simulation as a powerful tool. This will create a better understanding and improve generic, multi-modal therapy concepts and will ultimately result in an increased level of personalized treatment.

Work Packages

WP 1 - Targeted Drug Delivery using Focused Ultrasound Technology

The ultimate target of this work package is to investigate if selective blood-brain barrier openings under a MR-guided focused ultrasound application are able to deliver therapeutic agents to achieve a non-invasive treatment for neurodegeneration and tumors.

Project partners: Vartan Kurtcuoglu - Laboratory of Thermodynamics in Emerging Technologies, ETH Zurich
Niels Kuster - IT'IS Foundation
Ernst Martin - MR-Center, University Children’s Hospital
Dimos Poulikakos - Laboratory of Thermodynamics in Emerging Technologies, ETH Zurich
Beat Werner - MR-Center, University Children’s Hospital

 

WP 2 - Neuronavigation for Brain Tumor Surgery

The core objective of this activity will be to create a tool for neurosurgical navigation. This tool will allow the identification, 3D visualization and tracking of essential anatomical and functional structures by relying on pre- and intra-operative image data.

Project partners: Charles Baur - Robotic Systems Laboratory, EPF Lausanne
Gabor Szekely - Computer Vision Laboratory, ETH Zurich

 

WP 3 - Modeling Vascularized Solid Tumour Growth

This work package aims at modeling and simulating malignant glioma growth in view of therapeutic approaches and for individual treatment planning.

Project partners: Sven Hirsch - Computer Vision Lab, ETH Zürich
Petros Koumoutsakos - Computational Science & Engineering Laboratory, ETH Zurich
Ruth Kroschewski - Institute of Biochemistry, ETH Zurich
Markus Rudin - Institute for Biomedical Engineering, ETH Zurich
Gabor Szekely - Computer Vision Laboratory, ETH Zurich

 

Project Coordination

Project Leader: Gabor Szekely - Computer Vision Laboratory, ETH Zurich
Deputy: Sven Hirsch - Computer Vision Lab, ETH Zürich
Beat Werner - MR-Center, University Children’s Hospital


Last update on 2009-05-19.                                                                                                                                                                                                                                                

Last update 2009-10-27
The National Centres of Competence in Research (NCCR) are a research instrument of the Swiss National Science Foundation.