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01 Computer Aided and Image Guided Support for the Treatment of Neurodegeneration and Brain Tumours
The overall aim of this project is to develop a more effective and
less invasive treatment for neurological diseases such as
neurodegeneration and brain tumours.
In order to achieve a targeted delivery of therapeutic agents to
the Central Nervous System, this project explores the potential of
applying focused ultrasound to the non-invasive temporal openings of
the blood-brain barrier. It will also clarify the conditions needed
for a safe human application to blood-brain barrier openings and
prepare the first clinical studies for Alzheimer treatment.
Research will be conducted jointly with the NCCR Neural Plasticity and Repair.
At the same time, basic and clinical research in glioma formation
and image guided tumor surgery will be carried out. This research will
address the multiscale, physical, chemical and physiological modeling
of glioma development and infiltration. It will also focus on
neuronavigation for the resection of cortical and deep seated brain
tumors. This work pushes the precision limits of current
neuronavigation approaches and aims at establishing simulation as a
powerful tool. This will create a better understanding and improve
generic, multi-modal therapy concepts and will ultimately result in an
increased level of personalized treatment.
Work Packages
WP 1 - Targeted Drug Delivery using Focused Ultrasound Technology
The ultimate target of this work package is to investigate if
selective blood-brain barrier openings under a MR-guided focused
ultrasound application are able to deliver therapeutic agents to
achieve a non-invasive treatment for neurodegeneration and tumors.
WP 2 - Neuronavigation for Brain Tumor Surgery
The core objective of this activity will be to create a tool for
neurosurgical navigation. This tool will allow the identification, 3D
visualization and tracking of essential anatomical and functional
structures by relying on pre- and intra-operative image data.
WP 3 - Modeling Vascularized Solid Tumour Growth
This work package aims at modeling and simulating malignant glioma
growth in view of therapeutic approaches and for individual treatment
planning.
Project Coordination
Last update on 2009-05-19.
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